| Drug | Adult Dose | Peds Dose | Route | Key Notes |
| Epinephrine 1:1,000 | 0.3 mg IM ×2 | 0.01 mg/kg IM; max 0.3 mg ×2 | IM / auto-inj | Anaphylaxis, severe asthma |
| Epinephrine 1:10,000 | 1 mg IV/IO q5 min (arrest) | 0.01 mg/kg IV/IO (1–8 yr); 1 mg (9–14 yr) | IV/IO | Arrest, persistent anaphylaxis |
| Push Dose Epi 0.01 mg/ml | 1 ml q1–5 min | 0.1 ml/kg q1–5 min | IV/IO | Mix: 1 ml Epi 1:10,000 + 9 ml NS |
| Fentanyl | 50 mcg IV/IO q5 min; max 200 | 0.5 mcg/kg IV/IO; max 50 mcg/dose | IV/IO/IM/IN | Pain, cardiac chest pain, pacing/cardioversion |
| Midazolam | 2.5 mg IV/IO; 5 mg IM/IN | 0.1 mg/kg IV/IO (max 2.5); 0.2 mg/kg IM/IN (max 5) | IV/IO/IM/IN | Seizures, agitation, sedation for procedures |
| Naloxone | 0.5 mg q2–3 min; max 10 mg; fentanyl OD: 4 mg IN load | <8 yr: 0.1 mg/kg (max 0.5 mg); 9–14 yr: 0.5 mg | IV/IO/IM/IN | Suspected opioid OD with respiratory depression |
| D10W | 25 gm (250 ml) IV/IO bolus (BG <80) | 0.5 gm/kg (5 ml/kg) (neonate BG <35; peds BG <60) | IV/IO | LALS + ALS only |
| Adenosine | 6 mg → 12 mg → 12 mg IVP + 20 cc NS flush | N/A (adult protocol applies) | IV only | SVT, wide complex tach |
| Atropine | 1 mg IV/IO q5 min; max 3 mg or 0.04 mg/kg | OPP: 0.05 mg/kg; max 2 mg; repeat 0.1 mg/kg q5 min | IV/IO | Bradycardia, organophosphate poisoning |
| Lidocaine (cardiac) | 1.5 mg/kg; repeat 0.75 mg/kg; max 3 mg/kg | 1.0 mg/kg; repeat 0.5 mg/kg after 5 min; max 3 mg/kg | IV/IO | VF/VT (pulseless and with pulses) |
| NTG | 0.4 mg SL q3 min; paste 1 inch ×1 | N/A | SL/transmucosal/transdermal | CI: shock, RVI, phosphodiesterase inhibitors (48 hr) |
| Aspirin | 325 mg chewed | N/A | PO | ACS; LALS + ALS |
| Magnesium Sulfate | Eclampsia: 4 gm IVP over 3–4 min; Polymorphic VT: 2 gm IV over 5 min | Severe asthma (BHO): 50 mg/kg; max 2 gm over 20 min | IV/IO | BHO for asthma; drip 10 mg/min post-eclampsia seizure |
| TXA | 2 gm slow IV/IO over 1 min OR 1 gm IM (2×5 ml) | N/A (≥15 yr) | IV/IO/IM | Hemorrhagic shock; postpartum (BHO) |
| Ketamine | 0.3 mg/kg (max 30 mg) in 50–100 ml NS over 5 min; repeat ×1 after 15 min if pain ≥5 | N/A (adult only in ICEMA) | IV drip ONLY | Do NOT give IVP/IO/IM/IN; trauma/burns/abd/cancer/sickle cell |
| Ondansetron | 4 mg; repeat ×2 at 10 min; max 12 mg (≥9 yr) | 4–8 yr: max 4 mg total before BH contact | IV/IO/ODT | Nausea/vomiting; prophylactic with narcotics |
| Diphenhydramine | 25 mg IV/IO; 50 mg IM | 1 mg/kg IV (max 25 mg); 2 mg/kg IM (max 50 mg) | IV/IO/IM | Allergic reaction |
| Calcium Chloride | 1 gm (10 ml of 10% solution) IV/IO | CCB OD (BHO): 20 mg/kg IV/IO over 5 min | IV/IO | BHO: CCB OD, cardiac arrest hypocalcemia/hyperkalemia, crush injury, ESRD hyperkalemia |
| Sodium Bicarb | 50 mEq IV/IO (cardiac arrest); 1 mEq/kg (TCA poisoning) | Same | IV/IO | BHO for cardiac arrest; TCA poisoning; crush hyperkalemia (no BHO needed) |
| Buprenorphine-Naloxone | 16 mg/4 mg SL; repeat 8 mg/2 mg after 10 min; max 24 mg/6 mg | N/A (≥16 yr) | SL | Opioid withdrawal (COWS ≥8); ALS only |
| Glucagon | 1 mg IM/SC/IN × 1 | 0.03 mg/kg IM/IN; repeat ×1 after 20 min; max 1 mg total | IM/SC/IN (or IV if BHO) | Hypoglycemia (no IV); beta-blocker poisoning (IV, BHO) |
| Albuterol | 2.5 mg neb ×3; MDI 4 puffs q10 min | Same | Neb/MDI | BLS/LALS (MDI); LALS/ALS (neb); crush hyperkalemia: continuous 7.5 mg neb |